Obesity as risk factor for lactic acidosis during nucleoside analogue treatment
نویسندگان
چکیده
منابع مشابه
A cautionary tale: fatal lactic acidosis complicating nucleoside analogue and metformin therapy.
mining subcellular localization of HCVgenomic RNA in lymphocytes. The aim of our study was merely to determine whether the cervical smear cells obtained from HCV-seropositive women were infected with HCV genomic RNA. We will include the subcellular staining of HCVinfected cells in our continuing study. FISH was performed in accordance with the protocol by Pinkel et al. [3]. The sequence of the ...
متن کاملBench-to-bedside review: Severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors
Nucleoside reverse transcriptase inhibitors (NRTIs) are effective antiretroviral therapy for the treatment of HIV-infected patients. NRTIs can induce mitochondrial impairment that leads to a number of adverse events, including symptomatic lactic acidosis. In the present review, we describe the underlying mechanism of NRTI-induced toxicity and the main clinical features of this infrequent, but s...
متن کاملLactic acidosis occurring during phenformin therapy.
Case history The patient was a 47-year-old woman who developed diabetes mellitus in 1965. She was initially controlled on chlorpropamide and phenformin. However, her diabetic control became less satisfactory and insulin therapy was substituted in October 1967. Subsequently her diabetes became unstable and phenformin 100-150 mg daily was added in November 1968. Since then her blood glucose level...
متن کاملTreatment of congenital lactic acidosis with dichloroacetate.
The term congenital lactic acidosis (CLA) refers to a group of inborn errors of mitochondrial metabolism variably characterised by progressive neuromuscular deterioration and accumulation of lactate and hydrogen ions in blood, urine and/or cerebrospinal fluid, frequently resulting in early death. The incidence and prevalence of CLA are unknown, although it has been estimated that there are appr...
متن کاملAn acyclic 5-nitroindazole nucleoside analogue as ambiguous nucleoside.
Acyclic nucleoside analogues with carboxamido- or nitro-substituted heterocyclic bases have been evaluated for their possible use as universal bases in oligodeoxynucleotides. The acyclic moiety endows the constructs with enough flexibility to allow good base stacking. The 5-nitroindazole analogue afforded the most stable duplexes among the acyclic derivatives with the least spread in Tm versus ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hepatology
سال: 2009
ISSN: 0270-9139
DOI: 10.1002/hep.23518